How to Resolve - Disk Cleanup cannot clean up drive?

Disk Cleanup cannot clean up drive

Running Vista Home Premium 64-bit, version 6.0.6002.18005, whenever I try to run Disk Cleanup I get the message "Disk Cleanup cannot clean up drive X:\.".
This happens regardless of drive chosen (C, D (factory image partition), or F (attached backup drive)),
and regardless of whether I am running it for my files only or those of all users.
It also happens when I boot up in safe mode. 
C: drive has 314 GB of 687 GB free.
It has NTFS file system.

Keys to the Problem Disk Cleanup cannot clean up drive

Download Error Fixer for Free Now

Charles,
First, verify that the time, date/year & time-zone are set correctly
Clear up your Temp File/Cache.
Clean up the system (clearing out all the temp/tmp folders, and included all offline content, clearing the browser tif, delete cookies, etc.
etc..
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(Important: One of the normal steps in eliminating malicious programs is to entirely delete the contents of all Temp folders.
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Best and easier to use - CCleaner.

Download the basic (slim) build via
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The basic (slim) build does not contain the disgusted Toolbar
DO NOT USE ANY Advanced cleaning options.
DO NOT TOUCH THE REGISTRY.
At least not for now.

Reboot.
UTC/GMT is 18:56 on Friday, July 20, 2012

Open Action Center by clicking the Start button Picture of the Start button, clicking Control Panel, and then, under System and Security, clicking Review your computer's status.

Update and run your antivirus software. Windows doesn't come with antivirus software, but Action Center can often monitor the antivirus software that you or your computer manufacturer have installed.

Another Safe way to Fix the Problem: Disk Cleanup cannot clean up drive:

How to Fix Disk Cleanup cannot clean up drive with SmartPCFixer?

1. Download SmartPCFixer . Install it on your system.  Click Scan, and it will perform a scan for your computer. The junk files will be shown in the scan result.

2. After the scan is finished, you can see the errors and problems need to be repaired. Click Fix All.

3. The Fixing part is finished, the speed of your computer will be much higher than before and the errors have been fixed.

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